Ohio Valley Wrestling in Louisville, Kentucky, whose alumni include Brock Lesnar, The Miz, John Cena, Dave Bautista and Randy Orton. was once a proud finishing school for young wrestlers who hoped for a chance at a career in big time, but times have changed. Acclaimed wrestler Al Snow clings to an old school wrestling philosophy with a heavy emphasis on storytelling, but in spite of the love of a few diehard fans, the gym struggles week to week to stay relevant enough to keep its doors open. Things have become so dire financially that Al has to sell a majority stake to a group of local businessmen including Matt Jones, the most popular radio personality in the state of Kentucky. Matt and the new ownership group have infused the struggling gym with much-needed cash but it still operates at a staggering loss.

With new owners in the picture, once-famous pro wrestler Al Snow has been given the summer to turn OVW's dire financial situation around. Wrestlers tells the story of a handful of eccentric misfits who attempt to come together to help Al save this historic gym while achieving their own wild dreams of wrestling professionally.