The opening theme of "I'll Take Manhattan" introduced Detective Danny Clover, a hardened New York City cop who worked homicide "from Times Square to Columbus Circle—the gaudiest, the most violent, the lonesomest mile in the world."Danny Clover narrated the tales of the Great White Way to the accompaniment of music by Wilbur Hatch and Alexander Courage, and the recreation of Manhattan's aural tapestry required the talents of three sound effects technicians (David Light, Ralph Cummings, Ross Murray).

Bill Anders was the show's announcer, as was Joe Walters.The supporting cast included regulars Charles Calvert (as Sgt. Gino Tartaglia) and Jack Kruschen (as Sgt. Muggavan), with episodic roles filled by television, radio, and film stars such as Eve McVeagh, and such radio actors as Irene Tedrow, Barney Phillips, Virginia Gregg, Anthony Barrett, Herb Butterfield, Lamont Johnson, Herb Ellis, Hy Averback, Edgar Barrier, Betty Lou Gerson, Cathy Lewis, Harry Bartell, Sheldon Leonard, Martha Wentworth, Lawrence Dobkin, Howard McNear, and Mary Jane Croft.