28 MAY 2019 · What is an ADC? Three major components define an ADC—the monoclonal antibody, a cytotoxic payload, and a molecular linker that covalently bridges the other two components. A successful ADC should be chemically and physiologically stable in blood stream, exert similar antigen binding pattern compared with the unconjugated antibody, and exhibit desired payload toxicological effects once internalized. https://www.creative-biolabs.com/adc/services.htm
28 MAY 2019 · All chemical linkers are of >95% purity and they are the basic building blocks for a successful ADC. Linkers facilitate the conjugation of ADC toxins to antibodies and in the meantime, they also dictate the release mechanism of an ADC. Proper linker selection will not only ease the process of obtaining the conjugate but also help enhance the chemical and serum stability of the ADC, such as val cit pab. https://www.creative-biolabs.com/adc/classify-adc-linkers-7.htm
28 MAY 2019 · ADC toxins target crucial intracellular pathways to induce cell death and they can be over 1000-fold more potent than chemo therapeutic agents. A large selection of ADC toxins range from common auristatins, maytansinoids, calicheamicins to more innovative toxins such as amatoxins, polyketomycin…. https://www.creative-biolabs.com/adc/classify-adc-toxins-6.htm
28 MAY 2019 · Ipatasertib shows a powerful inhibition of all protein kinase B (Akt) isoforms but a weak suppression towards other members of the protein kinase family. Treatments of both tumor xenograft mouse models and human cancer cell lines with ipatasertib showed a significant suppression of Akt signaling, leading to a disruption in cell cycle progression and reduced cancer cell viability. https://www.creative-biolabs.com/adc/ipatasertib-akt-inhibitor.htm
28 MAY 2019 · Multiple endogenous amino acids can serve as potential conjugation sites. However, to achieve more precisely controlled site-directed conjugations and subsequently a narrower distribution of drug-to-antibody ratio (DAR), special moieties with unique conjugation chemistries are engineered into antibody sequences in antibody design services. One downside in using the endogenous amino acids for ADC development is a heavily dispersed DAR conjugation caused by the non-uniform distribution of the conjugation sites, especially in the case of Lysine-based conjugations. https://www.creative-biolabs.com/adc/antibody-design-and-conjugation.htm
28 MAY 2019 · ADEPT antibody is regarded as an “indirect targeting method” that involves two steps. Firstly, a non-toxic antibody–enzyme fusion protein is applied to the tumor matrix and binds to the tumor cells via tumor-specific antigen recognized by the antibody. Upon binding, an inert small-molecule prodrug is then given. The prodrug is the substrate for the enzyme portion of the antibody–enzyme fusion that is anchored to the tumor surface. Once the prodrug reaches the enzyme, an active cytotoxic agent is produced by the enzyme and cause cancer cell death. https://www.creative-biolabs.com/adc/toxic-enzymes-adept.htm
28 MAY 2019 · The target-oriented high-quality ADC custom products are suitable for tasks such as proof-of-concept, target validation, as well as control to provide comparison in efficacy for new ADC development projects. https://www.creative-biolabs.com/adc/target-list-customized-adcs-1.htm
28 MAY 2019 · As the new generation of immunotherapy, ADCs are meticulously constituted bio-macromolecules with high potential in the treatment of cancer and various other diseases. The information gathered from in vitro analysis provides a guideline for ADC optimization and the downstream in vivo ADC assessment. https://www.creative-biolabs.com/adc/adc-in-vitro-analysis.htm
27 MAR 2019 · To retain antibody bioactivity, mild, near-physiological conditions are often used for conjugation reactions. Under these conditions, endogenous amino acids such as Lys and Cys are chemically reactive and can be used as conjugation sites. One downside in using the endogenous amino acids for ADC development is a heavily dispersed conjugation of DAR caused by the non-uniform distribution of the conjugation sites, especially in the case of Lysine-based conjugations. https://www.creative-biolabs.com/adc/antibody-design-and-conjugation.htm
27 MAR 2019 · During the development of effective and safe antibody-drug conjugates some technical issues arose. The generation of an appropriate chemical linkers between the monoclonal antibody and the cytotoxic drug turns out to be a major difficulty. This is due to the complex synthesis of linker chemistry. On the other hand, the design of types of linkers is highly dependent on the target cells biology, the antibody characteristics, and the molecule structure of the drug. With the development of ADCs introduced to clinical trials or approved by the FDA, a series of typical linkers are now in use. https://www.creative-biolabs.com/adc/linker-module.htm
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