All odds are provided by Bet ESPN. Please gamble responsibly.

Week 1 of the NFL season brings a trove of exciting opportunities for football betting enthusiasts. Key matchups and betting lines have been highlighted to help fans make informed decisions.

One of the prominent games this week features the Arizona Cardinals visiting the Buffalo Bills. The betting line sees Buffalo favored by 6.5 points, with an over/under set at 47.5 points. Bettors can also explore the moneyline for more straightforward win/loss bets.

The contest between the Philadelphia Eagles and Green Bay Packers is another significant matchup this week. Detailed odds and best bets for this game are of particular interest to bettors looking for the most favorable positions. As always, it's essential to compare and contrast the various odds offerings to find potential value.

The Rhode Island Scumbag has highlighted a few of their favorites, including the Raiders, Falcons, and Panthers. These picks might appeal to those looking to take a chance on underdogs or less popular team selections.

For those involved in daily fantasy football, The Huddle provides a comprehensive Vegas odds chart to aid in DFS lineup decisions. This snapshot offers a quick look at betting lines and odds, supporting both sports betting and daily fantasy football action.

In summary, the NFL Week 1 odds offer plenty of betting opportunities across multiple games. Whether you're interested in point spreads, over/under totals, or moneylines, it’s crucial to stay updated with the latest betting information. Always remember to gamble responsibly and factor in all available data when making your decisions.