Lawerence and Leo explore Ellie's childhood, and how the tragedies of her past have come to define her.
They discuss Ellie's upbringing (6:50), the horrible way she learned about her CBI immunity (18:07), and speculate about her growth in The Last of Us 2 (28:20).
This is an [Expert] level episode, which means some parts of the  discussion may not make sense unless you’ve played the game. Expect lots  of spoilers.