Ipatasertib shows a powerful inhibition of all protein kinase B (Akt) isoforms but a weak suppression towards other members of the protein kinase family. Treatments of both tumor xenograft mouse models and human cancer cell lines with ipatasertib showed a significant suppression of Akt signaling, leading to a disruption in cell cycle progression and reduced cancer cell viability. https://www.creative-biolabs.com/adc/ipatasertib-akt-inhibitor.htm