Bhavya and Caleb attempt to jump inside the head of Handsome Jack and find the source of his insanity.
They discuss whether Jack has always been insane (1:25), the effect the Vault of the Sentinel had on him (7:25), and the possibility that Jack is self-aware enough to know that he is a villain (15:09).
This is an [Expert] level episode, which means some parts of the  discussion may not make sense unless you’ve played the game. Expect lots  of spoilers.