9. Pathogenesis 3

Aug 19, 2020 · 3m 24s
9. Pathogenesis 3
Description

MMPS — MATRIX METALO PROTEINASES Most important proteinase involved in destruction of periodontal tissue EG: MMP – 8, MMP – 13 GINGIVAL CREVICULAR FLUID  GCF has most abundance of...

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MMPS — MATRIX METALO PROTEINASES
Most important proteinase involved in destruction of
periodontal tissue
EG: MMP – 8, MMP – 13


GINGIVAL CREVICULAR FLUID

 GCF has most abundance of IgG
 CONTAINS
o Components of CT
o Epithelium
o Inflammatory cells
o Serum
o Microbial flora living there in the sulcus
 More neutrophils to defend the gingiva.
 Most drug concentration
o 1st tetracycline/doxycycline
o 2nd metronidazole
 DOXYCYCLINE – similar to tetracycline

QN Tetracycline cause brownish discoloration in all teeth & appear yellowish with UV light

 Pedo —20mg
 Therapeutic value — 100mg /day (Antibacterial dose)
 Sub antimicrobial dose = 20mg — bacteriostatic at GCF
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Information
Author Dr.Mayakha Mariam
Organization Dr.Mayakha Mariam
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